Karen Stern M.D. is an Associate Professor in the Department of Urology at Mayo Clinic Arizona in Phoenix, Arizona. She specializes in the medical and surgical management of complex stone disease. At Mayo Clinic she oversees the multi-disciplinary stone clinic which incorporates urology, nephrology, and dietetics in the management of recurrent stone formers. Her surgical practice includes complex ureteroscopy, mini-percutaneous nephrolithotomy, and ultrasound-guided percutaneous access for PCNL. She is involved in multiple ongoing clinical trials and is part of the Endourology Disease Group for Excellence (EDGE) and Collaborative for Research in Endourology (CoRE) research consortiums.  She received her M.D. from the University of Arizona, where she received the Alpha Omega Alpha distinction. She completed Urology residency at Mayo Clinic Arizona and was a Mayo Clinic Scholar during her Endourology fellowship at the Glickman Urological & Kidney Institute at Cleveland Clinic. She is the Program Director for the Endourology Fellowship at Mayo Clinic Arizona and takes an active role in medical student, resident, and fellow education. She was awarded the Donald E. Novicki MD Award for Excellence in Urologic Education in 2024. She is active within the American Urological Association and serves on the Legislative Affairs Committee and Public Policy Committee.